Dr. Frische

Rachel M. Frische, MD, MBA, MPH

Dr. Frische is a board-certified psychiatrist trained in general psychiatry, public health, and healthcare management. She has special interests in healthcare systems delivery, neurostimulation, and reproductive mood disorders. She enjoys working with men, women, and adolescents struggling with mood, anxiety, and psychotic disorders. Dr. Frische has worked extensively with medical professionals who experience symptoms of burnout and she also very much enjoys working with pregnant women and new mothers struggling with perinatal mood disorders.

She volunteers her time as adjunct assistant professor with the University of North Carolina Department of Psychiatry. Her particular research interests lie in the clinical application of technological innovations for the treatment of reproductive mood disorders and treatment-resistant depression.

Education & Training

  • University of North Carolina at Chapel Hill

General Psychiatry Residency Training

  • University of Missouri-Columbia School of Medicine

Medical Doctorate

  • Fort Hays State University

Master of Business Administration,

Concentration in Healthcare Management

  • University of Kansas School of Medicine

Master of Public Health (HONORS)

  • University of Missouri – Kansas City

Bachelor's of Arts in Biology & Liberal Arts

Chemistry Minor

Prior Experience

  • Medical Director of UNC Mental Health Specialists Clinic

  • Assistant Director of UNC's Taking Care of Our Own Program
    Wellness & Burnout Treatment Program for UNC Physicians

  • Attending Physician coverage of UNC Perinatal Inpatient Psychiatry Unit and Women's Mood Disorder Clinics

  • Attending Physician coverage of UNC Geriatric Inpatient Psychiatry Unit and Geriatric Psychiatry Clinics

  • Attending Physician of UNC Transcranial Magnetic Stimulation Clinic

Medical Licensure

North Carolina, 2019-01652

Board Certification

American Board of Psychiatry and Neurology


  • Krohn H, Guintivano J, Frische R, Steed J, Rackers H, Meltzer-Brody S; App-Based Ecological Momentary Assessment to Enhance Clinical Care for Postpartum Depression: Pilot Acceptability Study, Journal of JMIR Formative Research; 2022;6(3):e28081 (March, 23, 2022), https://formative.jmir.org/2022/3/e28081

  • Soda T, Richards J, Gaynes BN, Cueva M, Laux J, McClain C, Frische R, Lindquist LK, Cuddeback GS, Jarskog LF. Systematic Quality Improvement and Metabolic Monitoring for Individuals Taking Antipsychotic Drugs. Psychiatr Serv. 2021 Jun;72(6):647-653. https://pubmed.ncbi.nlm.nih.gov/33887956/

  • Cox EQ, Killenberg S, Frische R, et al. Repetitive transcranial magnetic stimulation for the treatment of postpartum depression. J Affect Disord. 2020;264:193-200. https://pubmed.ncbi.nlm.nih.gov/32056750/

  • Frische (2016, Jan). Manic and nonadherent, with a diagnosis of breast cancer; Current Psychiatry 15(1):51-57 https://cdn.mdedge.com/files/s3fs-public/issues/articles/0116CP_Cases_Rahman.pdf

  • Frische (2010, May). Feasibility of Recruitment and Differences in Completers of Tablet PC, Internet, and Paper Colon Cancer

Most Recent Publication

Dr. Frische is a contributing author for the recently published clinician textbook:

Women's Mood Disorders: A Clinician's Guide to Perinatal Psychiatry, SPRINGER NATURE, 2021.

In the media:

On a personal note...

I am originally from Kansas City, but moved to North Carolina for general psychiatry residency training at UNC. I love the Carolina blue skies and gorgeous greenery here. I am married, have three small children, and a dog. My family, friends, and patients bring meaning to my life.